The purpose of this study was to investigate the effectiveness of nursing care in epilepsy. In this experimental study, 120 nurses from hospitals in Isfahan were randomly divided into control and experimental groups (60 each). The data collection tool was a questionnaire based on nursing care in epilepsy. The case group received an educational program for one month and 3 months after the educational intervention, both groups completed the questionnaire and the data was analyzed. The findings of the study indicated that there was no significant difference between the two groups in terms of professional behavior, communication, personal approach, empathy and respect before the educational intervention, while after the intervention, the mentioned factors significantly increased in the experimental group, in comparison to the control group (p=0.001). Based on this study, the designed nursing care education program is effective in promoting nurses' professional behaviors, communication, personal approach, empathy and respect. In addition, educational control, monitoring and follow up are recommended in the implementation of these programs. Epilepsy is the most common neurological disorder in childhood. Nearly half of the cases of epilepsy occur in childhood. Epileptic children and their parents face many social and psychological problems. Problems of socialization, anxiety, cognitive impairment and behavioral disorders were observed in 39.8%, 45.8%, 49.4% and 42.2% of children with epilepsy, respectively. According to the local website of epilepsy, about 60 million people in the world suffer from epilepsy, where an average of between 125,000 and 150,000 are added to this infection, each year, from among which about 30% are children. One in 10 people has a seizure at least once in a lifetime. Нe rate of people with epilepsy in Iran is about 1 million. Up to now, therapeutic approaches based on nursing care have been proposed for epilepsy, which are effective in most cases and can certainty be used to treat epilepsy. Caring is at the center of nursing practices and in emphasizing the importance of nurse care role since 1990, Henchilof considers caring from the patient as the base of nursing and believes that, regardless of any changes that are made in the professional role of the nurse, caring from the patient as the basis of this profession. Caring along with respect and respecting for the life of a person is an integral part of the nursing role and responsibility. In this role, the nurse identities the total health care needs of the patient, including methods for emotional, spiritual and social welfare rehabilitation. In fact, caring helps both the patient and the family to compile goals and achieve them at minimum cost, time and energy. Also, due to the emphasis on resource management, cost control, the effectiveness of patient care, promotion of quality and accountability, good care of the patient is necessary. Nursing care has two aspects of emotions and activities, the first dimension is related to the attention to the patient as a person and paying attention to what happens to him. In other words, the emotional dimension of caring for dignity, the position and independence of the other person is respected. Нe dimension of activities is aimed at helping and serving others through nurse-patient communication. In fact, this dimension of care is about diagnosing and meeting the patient's needs. Нe overall aim of this study was to evaluate the effectiveness of nursing care in nursing staff on epilepsy nurses in Isfahan hospitals. Нe findings indicated that there was no significant difference between the mean score of professional behavior in intervention and control groups before educational intervention. Whereas, aÑ–er the intervention, the mentioned factors significant increased in the experimental group compared to the control group, but no significant difference was observed in the control group in the mean score of people regarding the professional behavior. Нe findings of this study indicated that the implementation of nursing care education program has been effective in improving nursing behaviors of the research units.